Discover the exceptional benefits of Citrulline Malate to optimize your sports performance
Introduction: Welcome to Stimium Laboratories, where our passion for citrulline, and more specifically citrulline malate, has led to a revolutionary advancement in the field of sports performance. In a world where each supplier touts the superiority of its ingredients, and where scientific studies abound, our experience in the pharmaceutical industry allows us to take a critical and transparent look at innovations. We are proud to present Stimium MC3, a product which, since its launch on the market in 2016, has proven its effectiveness, generating constant demand, both from occasional athletes and high-level athletes.
Why choose Stimium MC3:
Our flagship product, Stimium MC3 Powder, is a perfect fusion of L-citrulline, an essential amino acid, and malic acid, a key component of the tricarboxylic acid (TCA) cycle. This unique combination, the proportions of which remain confidential, offers exceptional benefits for sports performance.
Mechanism of action and advantages of Stimium MC3:
Citrulline Malate works in tandem with L-citrulline to deliver significant results. Malic acid, present in Stimium MC3, plays a crucial role in energy production, while L-citrulline helps eliminate ammonia, reducing muscle fatigue. Extensive studies reveal a notable reduction in the feeling of fatigue, a significant increase in ATP production during exercise, and faster phosphocreatine recovery after exercise.
The benefits of citrulline for sports performance:
Citrulline, an amino acid that our body can synthesize, is the key component of Stimium MC3. Its role goes beyond the elimination of ammonia, because it boosts the production of nitric oxide, improving vasodilation and cellular oxygenation. In addition, it promotes protein synthesis, strengthening muscles and improving resistance to exercise.
Recommended dosage and various uses:
Studies agree on a dosage of 2 to 5 grams per day, varying depending on the objectives. Whether you are a fan of bodybuilding, running, cycling, CrossFit, or other sports, Stimium MC3 offers significant benefits. Its use in preparation (Pre) or recovery (Post) adapts to different sports, from pure endurance to disciplines combining strength and endurance.
Conclusion :
Citrulline Malate proves to be much more than just a recovery supplement. Its usefulness extends to various sporting disciplines, from athletics to functional sports, including bodybuilding and combat sports. Stimium MC3, with its exclusive formula, stands out as an essential partner for maximizing your sporting performance, by increasing your endurance, promoting muscle development, and reducing recovery times. Choose real efficiency with Stimium MC3 and give your best in every training session.
In your Nike, Adidas, Salomon or Hoka shoes, for a marathon, a simple run, a trail, a bike ride, Stimium supports you, in training, in preparation, as in competition, as the number 1 laboratory on recovery. With our range of food supplements, and in particular our MC3 product, based on citrulline malate, a very specific amino acid, and magnesium in a sugar-free gel stick, to better oxygenate the muscles and avoid cramps. To be able to choose your dose, MC3 also exists in powder , to be mixed with water in a bottle, for even easier taking, but always with this beneficial effect for the body and for health. If among our recovery products, the Stimium range also includes exercise drinks, isotonic drinks , or recovery powders mixing protein isolate, glucose and fructose , the number 1 nutrition product remains MC3, due to its proven effectiveness, for athletes and non-athletes alike (the drug Stimol is intended more for the elderly).
This review of the bibliography reinforces our idea that our citrulline malate is unique. However, if MC3 is today in France the number 1 product in the recovery segment, we at Stimium will try to broaden its scope of use, and will also ask the Stimium community to participate actively involved in these new products, which we are already working on.
References :
- Perez-Guisado J, Jakeman PM (2010) Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 24(5):1215–1222 Schwedhelm E, Maas R, Freese R, Jung D, Lukacs Z, Jambrecina Aet al (2008) Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric acid. oxide metabolism. Br J Clin Pharmacol 65(1):51–59
- Citrulline/malate promotes aerobic energy production in human exercising muscle. D Bendahan, JP Mattei, B Ghattas, S Confort-Gouny, ME Le Guern, PJ Cozzone Br J Sports Med 2002;36:282–289
- A critical review of citrulline malate supplementation and exercise performance Lewis A. Gough, Andy Sparks, Lars R. McNaughton, Matthew F. Higgins, Josh W. Newbury, Eric Trexler, Mark A. Faghy, Craig A. Bridge
- Effect of citrulline on post-exercise rating of perceived exertion, muscle soreness, and blood lactate levels: A systematic review and meta-analysis Hye Chang Rhim a,y, Sung Jong Kim a,y, Jewel Park a, Ki-Mo Jang
- Takeda K, Machida M, Kohara A, Omi N, Takemasa T (2011) Effects of citrulline supplementation on fatigue and exercise performance in mice. J Nutr Sci Vitaminol 57(3):246–250
- Stamler JS, Meissner G (2001) Physiology of nitric oxide in skeletal muscle. Physiol Rev 81(1):209–237
- Sindelar JJ, Milkowski AL (2012) Human safety controversies surrounding nitrate and nitrite in the diet. Nitric Oxide 26(4):259–266
- Owens DJ, Twist C, Cobley JN, Howatson G, Close GL (2019) Exercise-induced muscle damage: What is it, what causes it and what are the nutritional solutions? Eur J Sport Sci 19(1):71–85
- Moinard C, Nicolis I, Neveux N, Darquy S, Benazeth S, Cynober L (2008) Dose-ranging effects of citrulline administration on plasma amino acids and hormonal patterns in healthy subjects: The citrudose pharmacokinetic study. Br J Nutr 99(4):855–862
- Lucero AA, Addae G, Lawrence W, Neway B, Credeur DP, Faulkner J, Stoner L (2018) Reliability of muscle blood flow and oxygen consumption response from exercise using near-infrared spectroscopy. Exp Physiol 103(1):90–100
- Jones AM, Vanhatalo A, Seals DR, Rossman MJ, Piknova B, Jonvik KL (2020) Dietary nitrate and nitric oxide metabolism: mouth, circulation, skeletal muscle, and exercise performance. Med Sci Sports Exerc 53(2):280–294
- Inman LA, Rennie MJ, Watsford ML, Gibbs NJ, Green J et al (2018) Reference values for the creatine kinase response to professional Australian football match play. J Sci Med Sport 21(8):852–857
- Hwang P, Morales Marroquin FE, Gann J, Andre T, McKinley-Barnard S, Kim C et al (2018b) Eight weeks of resistance training in conjunction with glutathione and L-citrulline supplementation increases lean mass and has no adverse effects on blood clinically European Journal of Applied Physiology 1 3 safety markers in resistance-trained males. J Int Soc Sports Nutr 15(1):30
- Hultström M, Amorim de Paula C, Fontes AP, M., Porcelli, S., Bellistri, G., Pugliese, L., et al (2015) Commentaries on Viewpoint: Can elite athletes benefit from dietary nitrate supplementation? J Appl Physiol 119(6):762–769
- Hargreaves M, Spriet LL (2020) Skeletal muscle energy metabolism during exercise. Nat Metab 2:817–828
- Grimble GK (2007) Adverse gastrointestinal effects of arginine and related amino acids. J Nutr 6(2):1693–1701
- Gonzalez AM, Trexler ET (2020) Effects of citrulline supplementation on exercise performance in humans: A review of the current literature. J Strength Cond Res 34(5):1480–1495
- Gonzalez AM, Spitz RW, Ghigiarelli JJ, Sell KM, Mangine GT (2018) Acute effect of citrulline malate supplementation on upper-body resistance exercise performance in recreationally resistance trained men. J Strength Cond Res 32(11):3088–3094
- Glenn JM, Gray M, Wethington LN, Stone MS, Stewart RW, Middle NE (2017) Acute citrulline malate supplementation improves upper- and lower-body submaximal weightlifting exercise performance in resistance-trained females. Eur J Nutr 56(2):775–784
- Gills JL, Glenn JM, Gray M, Romer B, Lu H (2021) Acute citrullinemalate supplementation is ineffective during aerobic cycling and subsequent anaerobic performance in recreationally active males. Eur J Sport Sci 18:1–7
- Gibala MJ, Young ME, Taegtmeyer H (2000) Anaplerosis of the citric acid cycle: role in energy metabolism of heart and skeletal muscle. Acta Physiol Scand 168(4):657–665
- Farney TM, Bliss MV, Hearon CM, Salazar DA (2019) The effect of citrulline malate supplementation on muscle fatigue among healthy participants. J Strength Cond Res 33(9):2464–2470
- Ehlers GG, Ball TE, Liston L (2002) Creatine kinase levels are elevated during 2-a-day practices in collegiate football players. J Athl Train 37(2):151
- Currell K, Jeukendrup AE (2008) Validity, reliability and sensitivity of measures of sporting performance. Sports Med 38:297–316
- Cunnife B, Papageorgiou M, O'Brien B, Davies NA, Grimble GK, Cardinale M (2016) Acute citrulline-malate supplementation and high-intensity cycling performance. J Strength Cond Res 30(9):2638–2647
- Casonatto J, Enokida DM, Grandolfi K (2019) Inter-Individual Responses to Citrulline Malate Oral Supplementation on PostExercise Hypotension in Hypertensives: A 24-Hour Analysis. Arq Bras Cardiol 113(2):218–228
- Breuillard C, Cynober L, Moinard C (2015) Citrulline and nitrogen homeostasis: an overview. Amino Acids 47(4):685–691
- Bendahan D, Mattei JP, Ghattas B, Confort-Gouny S, Le Guern ME, Cozzone PJ (2002) Citrulline/malate promotes aerobic energy production in human exercising muscle. Br J Sports Med 36(4):282–289
- Bahri S, Curis E, El Wafi FZ, Aussel C, Chaumeil JC, Cynober L, Zerrouk N (2008) Mechanisms and kinetics of citrulline uptake in a model of human intestinal epithelial cells. Clin Nutr 27(6):872–880
- Agudelo LZ, Ferreira DM, Dadvar S, Cervenka I, Ketscher L, Izadi M, Ruas JL (2019) Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efciency and fatigue-resistance. Nat Commun 10(1):1–12
